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Polygenic Risk Score (PRS) Calculations
Is there a way to calculate polygenic risk scores using RapidMiner Studio? My advisor instructed me to calculate polygenic risk scores (from a list of genes and their associated genetic variations (SNPs)). I have tried the website “Impute.me” and tried looking to use other programs in RStudio, however I am unsure what to do and maybe RapidMiner can do it all.
Would you be able to provide any help on polygenic risk score calculations? I would have a large genomic data set with SNPs and genotype information that I can upload to RapidMiner and a score will be given associated to each variation.
Thank you very much.